Current Project – NNBNI
Greg Goss (University of Alberta) and Geoff Sunahara (NRC-Biotechnology Research Institute), along with a strong, interdisciplinary team of researchers from academia, NRC institutes, and industry, have been awarded a grant from the NRC-NSERC-BDC Nanotechnology Initiative entitled “New Technologies and Strategies for Assessment of Manufactured Nanomaterial Toxicity”.
Theme 1 – Production and characterization of nanoparticles
The primary focus of Theme 1 is to coordinate the research expertise of the physicists and chemists involved in the production of novel, relevant Nanomaterials (NMs) with that of researchers involved in the testing industry so as to characterize the general properties of NMs critical to their environmental deposition, bioactivity, and ultimate fate.
Theme 2 – Characterization and Behaviour of NM in the aquatic environment and new methods for detection in aquatic matrices
The primary focus of Theme 2 is the development of novel methods for the detection and characterization of NMs in the environment and in complex biological samples. Sensitive analytical techniques are required to assess the extent of NM contamination in the environment and to accurately address NM dosing in target and non-target organisms.
Theme 3 - Methods for Biological Effects Testing
The primary focus of Theme 3 is to test particles generated in Theme 1 and reveal common, predictive characteristics of NM toxicity. Testing particles in a systematic manner using current, standardized toxicity tests in addition to newly developed tests (i.e. –omics tools and high-throughput, in vitro methods), the group will inform the regulators and risk assessors in Theme 4 as to the potential hazards associated with specific NMs.
Theme 4 - Science to Inform the Development of Sound Regulatory Policy
The objective of Theme 4 is to establish a collaborative dialogue between key stakeholders, including academia, government, industry and the public, to ensure that science-based evidence is used appropriately to inform the rational evolution of toxicological test methods for NMs.